I see music artists play with form and genre all the time, and usually it works out for them. Obviously it's hard to make a song everyone will like, but playing with form or genre will definitely grab the attention of listeners. An artist that I know of that has done this a lot is Bjork. For some people Bjork's music is weird, but for some it's very unique and fun to listen to. My sister June listens to her more than I do, but from what I've heard it's obvious that Bjork has paved her own genre into the music industry.
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